HPMC: Hydroxypropyl Methyl Cellulose / Hypromellose

HPMC is a multi-purpose pharmaceutical excipient. In the production of tablets, it is used as a film coating or adhesive agent. It can also significantly increase the dissolution rate as well as enhance the water-retention properties of a tablet.

The product can be used as a suspension, ophthalmic preparation, sustained-release reinforcing material and in floating tablets. Combined with other synthetic polymers and colloidal drugs, HPMC can prevent water and alcohol from separating from transparent gels and improve water retention properties. In addition, vegetable capsules are generally manufactured from HPMC.

Technical specification

Item Grade: 60HD (2910) Grade: 65HD (2906) Grade: 75HD (2208)
Methoxy (WT%) 28.0-30.0 27.0-30.0 19.0-24.0
Hydroxypropoxy (WT%) 7.0-12.0 4.0-7.5 4.0-12.0
Gelation temperature (˚C) 58.0-64.0 62.0-68.0 70.0-90.0
Viscosity (mPa.s) (2% solu., 20˚C) 3, 5, 6, 15, 50, 4000 50, 4000 100, 4000, 15000, 100000
Loss on drying (%)   ≤5.0  
Residue on ignition (%)   ≤1.5  
pH   4.0-8.0  
Heavy metals (ppm)   ≤20  
Arsenic (ppm)   ≤2.0  

Application suggestions

Headcel product Viscosity,
LV (2%, 25˚C)
Coating Control released agent Capsule Granulation/Binder Liquid Solutions
Headcel 60HD3 3 X        
Headcel 60HD5 5 X   X    
Headcel 60HD6 6 X   X    
Headcel 60HD15 15 X     X  
Headcel 60HD50 50 X     X  
Headcel 60HD4000 4000   X     X
Headcel 75HD100 100   X      
Headcel 75HD4000 4000   X      
Headcel 75HD15000 15000   X      
Headcel 75HD100000 100000   X      

Packing: 25kg fibre drum with inner liner, 450kg pallet, 9MT. in 20"FT FCL.